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SCH 2047069

KSP Inhibitor

SCH 2047069 is an orally active inhibitor of kinesin spindle protein (KSP), demonstrating a dissociation constant (Kd) of 0.5 nM and an IC50 value of ≤ 5 nM against KSP ATPase. This compound effectively crosses the blood-brain barrier and exhibits broad-spectrum antitumor activity, inducing mitotic arrest and apoptosis in various tumor cells. SCH 2047069 is relevant for research applications in cancer types such as ovarian cancer, colon cancer, glioblastoma, and lymphoma.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1146209-50-8
Applications	KSP Inhibitor
Formula	C₂₀H₁₇F₄N₃O₂S
Molecular Weight	439.43
Synonyms	MK-8267
SMILES	CC(N1N=C(C2=CC(F)=CC=C2F)S[C@@]31[C@H](CCN)COC4=CC(F)=C(F)C=C34)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.