SCH-23390 is a potent antagonist of dopamine D1-like receptors, exhibiting Ki values of 0.2 nM for the D1 subtype and 0.3 nM for the D5 subtype. This compound plays a significant role in behavioral research by shortening the latency period for cocaine-induced lever pressing in rat models. Additionally, SCH-23390 has been shown to eliminate generalized seizures induced by chemical convulsants, making it valuable in the study of neurological disorders associated with the dopamine system.
SCH-23390 is a potent antagonist of dopamine D1-like receptors, exhibiting Ki values of 0.2 nM for the D1 subtype and 0.3 nM for the D5 subtype. This compound plays a significant role in behavioral research by shortening the latency period for cocaine-induced lever pressing in rat models. Additionally, SCH-23390 has been shown to eliminate generalized seizures induced by chemical convulsants, making it valuable in the study of neurological disorders associated with the dopamine system.
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