Fig. 1 · Structure
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SCH79797 dihydrochloride
PAR1 Antagonist
SCH79797 dihydrochloride is a highly selective nonpeptide antagonist of protease-activated receptor 1 (PAR1). It effectively inhibits the binding of thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride demonstrates potent inhibition of thrombin-induced platelet aggregation, with an IC50 of 3 μM, and exhibits antiproliferative and pro-apoptotic effects. This compound also mitigates myocardial ischemia/reperfusion injury in rat cardiac models and prevents PAR1 activation in vascular smooth muscle, endothelial cells, and astrocytes, making it valuable for cardiovascular and neurobiological research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1216720-69-2 |
| Applications | PAR1 Antagonist |
| Formula | C23H27Cl2N5 |
| Molecular Weight | 444.40 |
| SMILES | Cl[H].Cl[H].NC1=NC(NC2CC2)=NC3=CC=C(N(CC4=CC=C(C(C)C)C=C4)C=C5)C5=C31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.