Fig. 1 · Structure
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SCR130
NHEJ Inhibitor
SCR130 is a selective inhibitor of DNA nonhomologous end-joining (NHEJ) that targets Ligase IV. By inhibiting the Ligase IV-mediated end-joining process, SCR130 effectively disrupts DNA repair mechanisms, leading to increased cell apoptosis. This compound demonstrates potential anticancer activity, making it a valuable tool for research applications in cancer biology and DNA repair studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2377858-38-1 |
| Applications | NHEJ Inhibitor |
| Formula | C19H13Cl2N3O2S |
| Molecular Weight | 418.30 |
| SMILES | O=C1NC(NC(C12N=C(CC2C3=CC=C(C=C3)Cl)C4=CC=C(Cl)C=C4)=O)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.