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Scyllatoxin

SK Channel Blocker

Scyllatoxin, also known as Leiurotoxin I, is a peptide toxin derived from the venom of the scorpion Leiurus quinquestriatus hebraeus. It specifically targets small-conductance calcium-activated potassium (SK) channels, functioning as a potent blocker. Scyllatoxin has been shown to enhance the release of norepinephrine and epinephrine in vivo, making it a valuable tool for research applications involving neurotransmitter regulation and ion channel function studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Blocker
CAS Number	142948-19-4
Applications	SK Channel Blocker
Formula	C₁₄₂H₂₃₇N₄₅O₃₉S₇
Molecular Weight	3423.15
Synonyms	Leiurotoxin I
SMILES	[C@H](CC1=CC=CC=C1)(C(N[C@@H]2C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@]3(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@]4(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@](CSSC2)(C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CN=CN5)C(N)=O)=O)CCCCN)=O)[C@H](C)C)=O)CSSC4)[H])[H])[H])[H])[H])=O)NC([C@H](C)N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.