Fig. 1 · Structure
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SDM-8
PET Radiopharmaceutical
SDM-8 is a difluoro-analogue of UCB-J, designed as a PET radiopharmaceutical targeting the synaptic vesicle protein SV2A. It demonstrates a high binding affinity, with a Ki of 0.58 nM, making it suitable for exploring synaptic function in neurological diseases. This compound is particularly relevant in research applications related to Alzheimer's disease, aiding in the investigation of disease mechanisms and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2242777-37-1 |
| Applications | PET Radiopharmaceutical |
| Formula | C17H16F2N2O |
| Molecular Weight | 302.32 |
| SMILES | O=C1C[C@H](C2=CC(F)=CC(F)=C2)CN1CC3=CC=NC=C3C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.