Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HaCaT | IC50 | 47 nM | Antiproliferative activity against human HaCaT cells after 3 days by sulforhodamine B assay | [PMID: 18678497] |
Fig. 1 · Structure
Documents & Downloads
SDZ281-977
SDZ281-977 is an antiproliferative agent. It acts by binding to the “colchicine binding site” on tubulin and inhibiting tubulin polymerization in vitro.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 150779-71-8 |
| Formula | C18H20O5 |
| Molecular Weight | 316.35 |
| Synonyms | SDZ-LAP 977 |
| SMILES | O=C(OC)C1=CC(CCC2=CC(OC)=CC=C2OC)=CC=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.