Fig. 1 · Structure
Documents & Downloads
Seco-DUBA
DUBA Prodrug
Seco-DUBA is a duocarmycin (DUBA) prodrug featuring two hydroxyl groups that enable the formation of covalent linkages with antibodies through linkers. This reagent serves as a crucial component in the synthesis of antibody-drug conjugates (ADCs), facilitating targeted delivery of cytotoxic agents to cancer cells. Its unique structure allows for versatile applications in therapeutic research and development, particularly in the field of targeted cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1227961-59-2 |
| Applications | DUBA Prodrug |
| Formula | C29H23ClN4O4 |
| Molecular Weight | 526.97 |
| SMILES | O=C(NC1=CN2C(C=C1)=NC(C(N3C[C@@H](CCl)C4=C3C=C(O)C5=CC=CC(C)=C45)=O)=C2)C6=CC=C(O)C=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.