Fig. 1 · Structure
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Sefaxersen sodium
CFB Inhibitor
Sefaxersen sodium is a specific antisense oligonucleotide (ASO) that targets complement factor B (CFB). It effectively reduces circulating levels of CFB, making it a valuable tool for research into geographic atrophy (GA). This compound facilitates the exploration of therapeutic strategies aimed at modulating the complement pathway in ocular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2272983-11-4 |
| Applications | CFB Inhibitor |
| Molecular Weight | 8678.96 (free acid) |
| Synonyms | IONIS-FB-LRx sodium; RG6299 sodium; ISIS 696844 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.