Fig. 1 · Structure
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Sefaxersen
CFB Inhibitor
Sefaxersen is a specific antisense oligonucleotide (ASO) that targets complement factor B (CFB), effectively decreasing its circulating levels. This compound plays a critical role in modulating the complement pathway and has significant implications for research related to geographic atrophy (GA). Researchers can utilize Sefaxersen to investigate the therapeutic potential in conditions characterized by complement dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2272975-74-1 |
| Applications | CFB Inhibitor |
| Molecular Weight | 9056.30 |
| Synonyms | IONIS-FB-LRx; RG6299; ISIS 696844 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.