Fig. 1 · Structure

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Segigratinib

Tyrosine Kinase Inhibitor

Segigratinib is a potent fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor. It exhibits significant antineoplastic activity, making it an important investigational reagent in cancer research. This compound is used to explore pathways involving FGFR signaling and its implications in tumorigenesis, providing insights into novel therapeutic strategies for malignancies associated with aberrant FGFR activity.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1882873-93-9
Applications Tyrosine Kinase Inhibitor
Formula C27H28Cl2N6O3
Molecular Weight 555.46
Synonyms 3D185 free base; HH185 free base
SMILES
O=C(C1=CC=C(N2CCNC(C)(C2)C)C=C1)NC3=NNC4=C3C=CC(C5=C(Cl)C(OC)=CC(OC)=C5Cl)=N4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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