Seletalisib (UCB-5857)

Catalog No.: A16797

PI3K inhibitor

Seletalisib (UCB-5857)

Seletalisib (UCB-5857) Chemical Structure

CAS NO. 1362850-20-1

Seletalisib is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).

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2 mg
$120.00
5 mg
$220.00
25 mg
$600.00
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Biological Activity

Seletalisib is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).
In vitro DMSO 89 mg/mL (184.32 mM)
Water Insoluble
Ethanol 89 mg/mL (184.32 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.71 mL 103.55 mL 207.1 mL
0.5 mM 4.14 mL 20.71 mL 41.42 mL
1 mM 2.07 mL 10.36 mL 20.71 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 482.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16797
Actions Inhibitor
CAS No. 1362850-20-1
Formula C23H14ClF3N6O
M. Wt 482.85
Purity >98%
Synonyms UCB-5857; UCB 5857; UCB5857; Seletalisib
SMILES FC(F)(F)[[email protected]@H](C1=CC2=CC=CC(Cl)=C2N=C1C3=CC=C[N+]([O-])=C3)NC4=C5C(C=CC=N5)=NC=N4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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