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Semorinemab
Semorinemab (RG 6100) is a humanized IgG4 monoclonal antibody designed to specifically target the N-terminal region of the Tau protein, encompassing amino acid residues 6-23. This antibody exhibits a high affinity for human Tau, with a dissociation constant (Kd) of 3.8 nM, indicating robust binding efficiency. Semorinemab is primarily utilized in the investigation of Alzheimer's Disease, serving as a critical tool in research focused on the pathophysiology and potential therapeutic interventions for tauopathies.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2159141-27-0 |
| Molecular Weight | 145100 |
| Synonyms | RG 6100; RO7105705; MTAU-9937A |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.