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Semorinemab

Semorinemab (RG 6100) is a humanized IgG4 monoclonal antibody designed to specifically target the N-terminal region of the Tau protein, encompassing amino acid residues 6-23. This antibody exhibits a high affinity for human Tau, with a dissociation constant (Kd) of 3.8 nM, indicating robust binding efficiency. Semorinemab is primarily utilized in the investigation of Alzheimer's Disease, serving as a critical tool in research focused on the pathophysiology and potential therapeutic interventions for tauopathies.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 2159141-27-0
Molecular Weight 145100
Synonyms RG 6100; RO7105705; MTAU-9937A

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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