SEN12333 is a potent and selective agonist of the α7 nicotinic acetylcholine receptor (nAChR). It demonstrates high affinity for rat α7 nAChRs, with a Ki value of 260 nM, and functions as a full agonist in calcium flux studies, achieving an EC50 of 1.6 μM. This compound is utilized in research focusing on Alzheimer's disease and schizophrenia, facilitating the exploration of therapeutic interventions targeting cholinergic signaling pathways.
SEN12333 is a potent and selective agonist of the α7 nicotinic acetylcholine receptor (nAChR). It demonstrates high affinity for rat α7 nAChRs, with a Ki value of 260 nM, and functions as a full agonist in calcium flux studies, achieving an EC50 of 1.6 μM. This compound is utilized in research focusing on Alzheimer's disease and schizophrenia, facilitating the exploration of therapeutic interventions targeting cholinergic signaling pathways.
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