Fig. 1 · Structure
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SEN12333
α7 nAChR Agonist
SEN12333 is a potent and selective agonist of the α7 nicotinic acetylcholine receptor (nAChR). It demonstrates high affinity for rat α7 nAChRs, with a Ki value of 260 nM, and functions as a full agonist in calcium flux studies, achieving an EC50 of 1.6 μM. This compound is utilized in research focusing on Alzheimer's disease and schizophrenia, facilitating the exploration of therapeutic interventions targeting cholinergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 874450-44-9 |
| Applications | α7 nAChR Agonist |
| Formula | C20H25N3O2 |
| Molecular Weight | 339.43 |
| Synonyms | WAY-317538 |
| SMILES | O=C(CCCCN1CCOCC1)NC2=CC=C(C3=CN=CC=C3)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.