Fig. 1 · Structure
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SEN205A
S100B Binder
SEN205A is a fragment compound that selectively binds to the hydrophobic pocket of human S100B, with a dissociation constant (Kd) ranging from 0.5 to 1.0 mM. This binding site is crucial for the interaction between S100B and both TRTK-12 and p53, with TRTK-12 capable of displacing SEN205A. Demonstrating favorable in vitro ADME properties, SEN205A displays high metabolic stability, chemical stability, and good solubility at physiological pH. It serves as a valuable starting fragment for structure-based optimization in the development of inhibitors targeting the S100B-p53 protein-protein interaction, contributing to research on the pathogenesis of malignant melanoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 958712-85-1 |
| Applications | S100B Binder |
| Formula | C13H14ClN3O |
| Molecular Weight | 263.73 |
| SMILES | ClC=1C=CC(=CC1)C2=NOC(=N2)C3CNCCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.