Fig. 1 · Structure
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Seneciphylline
Hepatotoxic Inducer
Seneciphylline is a hepatotoxic inducer that operates through metabolic activation by CYP450 enzymes, resulting in the formation of reactive intermediates. These intermediates covalently bind to biomacromolecules, including proteins and DNA, leading to the induction of cell apoptosis and mitochondrial dysfunction. Seneciphylline is valuable for research focused on elucidating mechanisms of hepatotoxicity and studying associated cellular pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 480-81-9 |
| Applications | Hepatotoxic Inducer |
| Formula | C18H23NO5 |
| Molecular Weight | 333.38 |
| SMILES | O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](C)(O)C(C/3)=C)=O)=CC2)C3=C/C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.