Fig. 1 · Structure
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Seviteronel racemate
Cytochrome P450 Inhibitor
Seviteronel racemate is a potent inhibitor of cytochrome P450 17A1 (CYP17), specifically targeting the lyase activity associated with this enzyme. With a low nanomolar IC50 value, it effectively disrupts steroidogenesis, making it valuable for research into conditions related to hormone regulation and hormonal therapies. This compound is suitable for studies focused on cancer biology, particularly in understanding the mechanisms underlying testosterone biosynthesis in prostate cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1375603-36-3 |
| Applications | Cytochrome P450 Inhibitor |
| Formula | C18H17F4N3O3 |
| Molecular Weight | 399.34 |
| Synonyms | VT-464 (racemate) |
| SMILES | FC(F)OC1=C(OC(F)F)C=C(C=CC(C(C2=CNN=N2)(C(C)C)O)=C3)C3=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.