Fig. 1 · Structure
Documents & Downloads
SG3199
PBD Dimer
SG3199 is a pyrrolobenzodiazepine (PBD) dimer that functions as a cytotoxic agent by inducing interstrand crosslinks in the minor groove of DNA. This compound plays a crucial role in targeted cancer therapy, particularly as the released warhead component of the antibody-drug conjugate (ADC) Tesirine (SG3249). Its ability to effectively disrupt DNA replication makes SG3199 a valuable reagent for research applications focused on cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1595275-71-0 |
| Applications | PBD Dimer |
| Formula | C33H36N4O6 |
| Molecular Weight | 584.66 |
| SMILES | O=C1N2[C@](CC(C)=C2)([H])C=NC3=CC(OCCCCCOC4=C(OC)C=C5C(N6[C@](CC(C)=C6)([H])C=NC5=C4)=O)=C(OC)C=C13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.