Fig. 1 · Structure
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SGC-CLK-1
CLK1/2/4 Inhibitor
SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. This compound exhibits significant anti-proliferative activity against melanoma and glioblastoma cell lines. It serves as a valuable tool for investigating the roles of these kinases in various biological processes and may aid in therapeutic development for related cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 748142-15-6 |
| Applications | CLK1/2/4 Inhibitor |
| Formula | C19H15F3N6O2 |
| Molecular Weight | 416.36 |
| Synonyms | CAF-170 |
| SMILES | FC(F)(C1=CC(NC2=NC=CC(C3=C4C=CC(OC)=NN4N=C3)=N2)=CC(OC)=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.