Fig. 1 · Structure
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SGD-1882
Pyrrolobenzodiazepine Dimer
SGD-1882 is a pyrrolobenzodiazepine (PBD) dimer that functions as a cytotoxic agent through DNA minor-groove crosslinking. Its mechanism allows for targeted delivery in antibody-drug conjugates (ADCs), making it a valuable reagent for cancer research. SGD-1882's biological activity enables the exploration of innovative therapeutic strategies in oncology, particularly in developing highly selective treatments for tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1222490-34-7 |
| Applications | Pyrrolobenzodiazepine Dimer |
| Formula | C42H39N5O7 |
| Molecular Weight | 725.79 |
| Synonyms | PBD dimer |
| SMILES | O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.