Fig. 1 · Structure
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SH-42
DHCR24 Inhibitor
SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), demonstrating an IC50 of 42 nM. By inhibiting DHCR24, SH-42 effectively elevates plasma desmosterol levels in murine models. This compound is valuable for studying cholesterol metabolism and related disorders, making it a useful tool for research in lipid biochemistry and cardiovascular studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2143952-36-5 |
| Applications | DHCR24 Inhibitor |
| Formula | C25H38O4 |
| Molecular Weight | 402.57 |
| SMILES | C[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)COC=O)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.