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SH1573

Name: SH1573
Brand: Adooq Bioscience
SKU: A75810
Availability: OutOfStock

Cat. No. A75810 CAS 2376068-96-9

mIDH2 Inhibitor

SH1573 is an orally active inhibitor of mutant isocitrate dehydrogenase 2 (mIDH2). It exhibits a strong and selective inhibitory effect on the mIDH2 R140Q variant, with an IC50 value of 4.78 nmol/L, effectively reducing the production of the oncogenic metabolite 2-hydroxyglutarate (2-HG) in various biological contexts, including animal models, cell lines, and tumors. SH1573 is designed for research applications in acute myeloid leukemia (AML) to investigate potential therapeutic strategies targeting mIDH2 mutations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2376068-96-9
Applications	mIDH2 Inhibitor
Formula	C₂₁H₁₈F₉N₇O₄S
Molecular Weight	635.46
SMILES	FC(F)(F)C1=CC=CC(C2=NC(N3C[C@@](C(F)(F)F)(O)CC3)=NC(NC4=CC(C(F)(F)F)=NC=C4)=N2)=N1.CS(O)(=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.