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SH491

Antiosteoporosis Agent

SH491 is an antiosteoporosis agent that inhibits receptor activator of nuclear factor kappa-B ligand (RANKL)-induced differentiation of osteoclasts from bone-marrow-derived monocytes (BMMs) with an IC50 value of 11.8 nM. This compound downregulates the expression of osteoclastogenesis-related marker genes, including TRAP, CTSK, MMP-9, and ATPase v0d2, as well as their associated protein products. SH491 may be valuable for research focused on osteoporosis and related bone disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	2975285-28-8
Applications	Antiosteoporosis Agent
Formula	C₃₃H₅₀N₂O
Molecular Weight	490.76
SMILES	C[C@]12[C@]([H])(C(C)(C)C3=C(C2)C=NC(C)=N3)CC[C@@]4([C@@]1(C[C@H]([C@]5([C@]4(CC[C@@H]5C(CC/C=C(C)\C)=C)C)[H])O)[H])C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.