Fig. 1 · Structure
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SH514
IRF4 Inhibitor
SH514 is a potent IRF4 inhibitor that demonstrates an IC50 of 2.63 μM. It targets the IRF4-DBD domain, effectively disrupting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 reduces the proliferation of IRF4-high-expressing NCI-H929 and MM.1R multiple myeloma cells without harming normal cells. This compound downregulates the expression of key downstream target genes and cell cycle-related proteins, including CDC2 and Cyclin B1, while inducing DNA damage as indicated by increased γH2AX expression. SH514 serves as a valuable tool for investigating therapeutic strategies in multiple myeloma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3099543-90-2 |
| Applications | IRF4 Inhibitor |
| Formula | C32H38N2O4 |
| Molecular Weight | 514.66 |
| SMILES | C[C@]12CC[C@@]3([H])[C@@]([H])(C(C=C4C(C)(C(C(C#N)=C[C@@]43C)=O)C)=O)[C@]1([H])CC[C@@H]2[C@@H](C(NC5=CC=C(C=C5)OC)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.