Fig. 1 · Structure
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SHIP1 activator 1
Phosphatase
SHIP1 activator 1 is a selective regulator of the SH3 domain-containing inositol 5-phosphatase, SHIP1, that enhances its activity. This compound effectively activates SHIP1 in vitro, leading to the inhibition of Akt phosphorylation in MOLT-4 cells. Furthermore, it demonstrates dose-dependent efficacy in a mouse model of inflammation. SHIP1 activator 1 serves as an essential tool for investigating the role of SHIP1 activators in the modulation of hematopoietic diseases associated with dysregulated PI3K signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1000010-33-2 |
| Applications | Phosphatase |
| Formula | C21H30O2 |
| Molecular Weight | 314.46 |
| SMILES | OC1=CC(O)=CC2=C1[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.