Fig. 1 · Structure
Documents & Downloads
SHP2-D26
SHP2 Degrader
SHP2-D26 is a potent SHP2 degrader that functions as a PROTAC by facilitating the recruitment of the VHL-1 E3 ligase to the SHP2 protein. This dual-target mechanism efficiently induces the degradation of SHP2 in a neddylation- and proteasome-dependent manner. SHP2-D26 is valuable for research applications in understanding esophageal cancer and acute myeloid leukemia, providing insights into SHP2's role in these malignancies.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2458219-65-1 |
| Applications | SHP2 Degrader |
| Formula | C56H79ClN12O6S2 |
| Molecular Weight | 1115.89 |
| SMILES | ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.