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SHP2-IN-27

SH2 Inhibitor

SHP2-IN-27 is an allosteric inhibitor targeting the SH2 domain of SHP2 (Src homology 2 domain-containing phosphatase-2). This compound has demonstrated effective inhibition of SHP2's enzymatic activity, contributing to downstream signaling modulation. SHP2-IN-27 is particularly relevant in cancer research, where SHP2 plays a pivotal role in tumor cell proliferation and survival. This reagent is useful for studies focused on the development of therapies that disrupt aberrant signaling pathways associated with malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2376012-00-7
Applications	SH2 Inhibitor
Formula	C₂₁H₂₂ClN₇
Molecular Weight	407.90
SMILES	N[C@H](C[C@@H]1CC2)C[C@@H]2N1C3=CN=C4C(NC=C4C5=C(Cl)C6=CN(C)N=C6C=C5)=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.