Fig. 1 · Structure
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SHR5428
CDK7 Inhibitor
SHR5428 is a selective and noncovalent inhibitor of cyclin-dependent kinase 7 (CDK7), exhibiting potent enzymatic activity with an IC50 of 2.3 nM. This compound effectively inhibits cellular activity in triple-negative breast cancer models, specifically in MDA-MB-468 cells, with an IC50 of 6.6 nM. SHR5428 is suitable for research applications involving cell cycle regulation and therapeutic development for aggressive breast cancer forms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3054791-71-5 |
| Applications | CDK7 Inhibitor |
| Formula | C22H23F3N5O2P |
| Molecular Weight | 477.42 |
| SMILES | CP(C1=C(C=CC2=C1NC=C2C3=C(C=NC(N[C@@H]4C[C@H](CCC4)O)=N3)C(F)(F)F)C#N)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.