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SHY-867

Ras Inhibitor

SHY-867 is a pan-Ras inhibitor that prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases, exhibiting EC50 values between 0.5-3 μM. This compound effectively inhibits the phosphorylation of critical downstream signaling molecules, including MEK, ERK1/2, and AKT. SHY-867 is a valuable tool for research applications focusing on pancreatic cancer and non-small cell lung cancer, facilitating investigations into Ras-GTP activity and related molecular pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2446484-96-2
Applications	Ras Inhibitor
Formula	C₂₆H₂₇N₇OS
Molecular Weight	485.60
SMILES	CO[C@H]1CC[C@H](C1)NC2=NC(C3=NC=CN3C)=NC4=C2C(C5=CC=CC=C5)=C(S4)C6=NN(C=C6)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.