Si5-N14 is a siloxane-based lipid nanoparticle component that enhances vascular repair and exhibits anti-tumor properties. It effectively facilitates CRISPR-Cas9 editing in transgenic GFP mice and demonstrates an ability to knock out Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in Lewis lung carcinoma models, contributing to tumor suppression. Additionally, Si5-N14 has been shown to deliver Fibroblast Growth Factor-2 (FGF-2) mRNA in models of viral-induced lung injury, promoting vascular repair, increasing blood oxygen levels, and enhancing lung function. This reagent holds significant potential for research applications in oncology, pulmonary disease, and cardiovascular health.
Si5-N14 is a siloxane-based lipid nanoparticle component that enhances vascular repair and exhibits anti-tumor properties. It effectively facilitates CRISPR-Cas9 editing in transgenic GFP mice and demonstrates an ability to knock out Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in Lewis lung carcinoma models, contributing to tumor suppression. Additionally, Si5-N14 has been shown to deliver Fibroblast Growth Factor-2 (FGF-2) mRNA in models of viral-induced lung injury, promoting vascular repair, increasing blood oxygen levels, and enhancing lung function. This reagent holds significant potential for research applications in oncology, pulmonary disease, and cardiovascular health.
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