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SIB 1663

nAChR Agonists

SIB 1663 is a conformationally restricted analog of nicotine that selectively activates α2β4 and α4β4 human recombinant neuronal nicotinic acetylcholine receptors (nAChRs). This compound has been shown to enhance the release of dopamine (DA) and norepinephrine (NE), making it a valuable tool in the study of neurotransmitter dynamics. SIB 1663 is applicable in neurological disease research, providing insights into the mechanisms underlying various neuropharmacological conditions.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	179064-11-0
Applications	nAChR Agonists
Formula	C₁₂H₁₆N₂O
Molecular Weight	204.27
SMILES	COC1=NC=C2C(CCC3CCNC23)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.