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Sibeprenlimab

Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody designed to inhibit the activity of a proliferation-inducing ligand (APRIL). This antibody selectively suppresses pathogenic immunoglobulins, specifically IgA and IgM, while maintaining effective antibody responses to mRNA-based SARS-CoV-2 vaccines. Additionally, Sibeprenlimab has demonstrated potential in reducing the urinary protein-to-creatinine ratio (UPCR) and stabilizing glomerular filtration rate (GFR), indicating its utility in the investigation of IgA nephropathy (IgAN). This makes Sibeprenlimab a valuable tool for research focused on autoimmune renal disorders and immune response modulation.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 2382896-07-1
Molecular Weight 146360
Synonyms VIS649

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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