Documents & Downloads
Sibeprenlimab
Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody designed to inhibit the activity of a proliferation-inducing ligand (APRIL). This antibody selectively suppresses pathogenic immunoglobulins, specifically IgA and IgM, while maintaining effective antibody responses to mRNA-based SARS-CoV-2 vaccines. Additionally, Sibeprenlimab has demonstrated potential in reducing the urinary protein-to-creatinine ratio (UPCR) and stabilizing glomerular filtration rate (GFR), indicating its utility in the investigation of IgA nephropathy (IgAN). This makes Sibeprenlimab a valuable tool for research focused on autoimmune renal disorders and immune response modulation.
In Stock
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2382896-07-1 |
| Molecular Weight | 146360 |
| Synonyms | VIS649 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.