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Sigma-1 receptor antagonist 5

H3R/σ1R Inhibitor

Sigma-1 receptor antagonist 5 is a selective antagonist of the sigma-1 receptor (Ki=4.5 nM) and the histamine H3 receptor (Ki=7.7 nM). This compound exhibits notable analgesic properties, effectively suppressing capsaicin-induced nociception. Sigma-1 receptor antagonist 5 is valuable for research applications related to nociceptive and neuropathic pain models, highlighting its potential for exploring pain mechanisms and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2952808-33-0
Applications	H3R/σ1R Inhibitor
Formula	C₂₆H₂₇N₃O
Molecular Weight	397.51
SMILES	N#CC1=CC=C(C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.