Fig. 1 · Structure
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Sigvotatug vedotin
ADC
Sigvotatug vedotin is an antibody-drug conjugate (ADC) designed to target integrin beta-6 (ITGB6) through the human IgG1 monoclonal antibody Sigvotatug. This conjugate demonstrates cytotoxic activity against various integrin beta-6-positive cancer cells by utilizing the potent mitotic inhibitor MMAE. It can be utilized in research applications focused on cancer therapeutics and targeted delivery mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2764774-91-4 |
| Applications | ADC |
| Molecular Weight | 150000 (average) |
| Synonyms | SGN-B6A; PF-08046047 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
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| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.