Fig. 1 · Structure
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Sildenafil-d3
Deuterium Labeled Sildenafil
Sildenafil-d3 is a deuterium-labeled derivative of Sildenafil, a well-characterized phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. This compound is primarily used in pharmacokinetic studies and metabolic profiling, providing valuable insights into the dynamics of Sildenafil in biological systems. The incorporation of deuterium allows for enhanced detection and quantification in analytical assays, facilitating research related to cardiovascular therapies and erectile dysfunction treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1126745-90-1 |
| Applications | Deuterium Labeled Sildenafil |
| Formula | C22H27D3N6O4S |
| Molecular Weight | 477.59 |
| Synonyms | UK-92480-d3 |
| SMILES | CCOC1=C(C=C(S(N2CCN(CC2)C([2H])([2H])[2H])(=O)=O)C=C1)C(NC3=C4N(N=C3CCC)C)=NC4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.