Fig. 1 · Structure
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Sildenafil-d3N-1
Deuterium Labeled Sildenafil
Sildenafil-d3N-1 is a deuterium-labeled derivative of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 5.22 nM. This isotopic variant is useful for studying the pharmacokinetics and metabolism of Sildenafil in biological systems. Its application extends to research involving erectile dysfunction, pulmonary hypertension, and the modulation of nitric oxide signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1126745-87-6 |
| Applications | Deuterium Labeled Sildenafil |
| Formula | C22H27D3N6O4S |
| Molecular Weight | 477.59 |
| Synonyms | UK-92480-d3N-1 |
| SMILES | CN1CCN(S(C2=C([2H])C([2H])=C(OCC)C(C3=NC(C(CCC)=NN4C)=C4C(N3)=O)=C2[2H])(=O)=O)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.