Fig. 1 · Structure
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Simufilam dihydrochloride
FLNA Modulator
Simufilam dihydrochloride is an orally active modulator of filamin A (FLNA) that functions by restoring normal FLNA conformation. This compound enhances N-methyl-D-aspartate receptor (NMDAR) signaling and Arc expression while inhibiting overactive mTOR signaling pathways. Additionally, Simufilam dihydrochloride improves insulin sensitivity and reduces neuroinflammation and tau hyperphosphorylation induced by Aβ42. It is primarily utilized in research focused on Alzheimer's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2480226-06-8 |
| Applications | FLNA Modulator |
| Formula | C15H23Cl2N3O |
| Molecular Weight | 332.27 |
| Synonyms | PTI-125 dihydrochloride |
| SMILES | O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.