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Simurosertib

CDC7 inhibitor

Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM.

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Biological Activity

Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM.

Target & Activity

Target	Activity	Value
Cdc7	IC50	<0.3 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
COLO 205	EC50	81 nM	Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay	[PMID: 31895562]
HeLa	IC50	17 nM	Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis	[PMID: 31895562]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1330782-76-7
Applications	CDC7 inhibitor
Formula	C₁₇H₁₉N₅OS
Molecular Weight	341.43
Synonyms	TAK-931
SMILES	O=C1C2=C(C=C(C3=CNN=C3C)S2)NC([C@H]4N(CC5)CCC5C4)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.