Fig. 1 · Structure
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Simvastatin acid ammonium
HMGCR Inhibitor
Simvastatin acid ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). It effectively reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes, highlighting its potential to combat oxidative stress in cardiac tissues. Additionally, Simvastatin acid ammonium has been shown to modulate OATP3A1 expression in both cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene, making it relevant for studies exploring drug transport mechanisms and cardiac pathology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 139893-43-9 |
| Applications | HMGCR Inhibitor |
| Formula | C25H43NO6 |
| Molecular Weight | 453.61 |
| Synonyms | Tenivastatin ammonium |
| SMILES | O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)[O-].[NH4+] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.