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Sirukumab
Sirukumab (CNTO-136) is a humanized monoclonal IgG1κ antibody targeting IL-6 (Interleukin-6). By binding to IL-6, Sirukumab inhibits IL-6-mediated signal transduction, effectively preventing the activation of transcriptional activators involved in inflammatory responses. This blockade curtails the downstream biological effects associated with IL-6 activity. Sirukumab is primarily utilized in research focused on active lupus nephritis and rheumatoid arthritis, offering significant insights into the pathophysiology and potential therapeutic interventions for these conditions.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1194585-53-9 |
| Molecular Weight | 144580 |
| Synonyms | CNTO-136 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.