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SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.28 mL | 136.39 mL | 272.78 mL |
| 0.5 mM | 5.46 mL | 27.28 mL | 54.56 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.28 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18463 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 366.6 |
| Formula | C21H38N2OS |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2374313-54-7 |
| Synonyms | SIS-17; SIS 17; SIS17; |
| SMILES | O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC |
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