Fig. 1 · Structure
Documents & Downloads
Sitravatinib malate
RTK Inhibitor
Sitravatinib malate is a potent orally bioavailable receptor tyrosine kinase (RTK) inhibitor, demonstrating impressive IC50 values of 0.5 to 29 nM against a range of targets including Axl, VEGFRs, and KIT. This compound exhibits robust antitumor activity as a single agent and enhances the effectiveness of PD-1 blockade by fostering a supportive antitumor immune microenvironment. Sitravatinib malate is valuable in cancer research, particularly in studies focused on RTK modulation and immune checkpoint therapy.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2244864-88-6 |
| Applications | RTK Inhibitor |
| Formula | C37H35F2N5O9S |
| Molecular Weight | 763.76 |
| Synonyms | MGCD516 malate; MG-516 malate |
| SMILES | O=C(O)[C@@H](O)CC(O)=O.O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CNCCOC)C=C6)S5)=NC=C4)C(F)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.