Fig. 1 · Structure
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SJ6145
KLHDC2 Ligand
SJ6145 is a potent ligand for KLHDC2, exhibiting a dissociation constant (Kd) of 16.9 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates an IC50 value of 42 μM in inhibiting KLHDC2's binding to a di-Gly degron peptide, highlighting its potential role in investigating KLHDC2-mediated cellular processes. SJ6145 can be utilized in research applications focused on protein degradation and regulatory mechanisms in cellular homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1010913-79-7 |
| Applications | KLHDC2 Ligand |
| Formula | C13H11FN2O3S |
| Molecular Weight | 294.30 |
| SMILES | O=C(CNC(CC1=CSC(C2=C(C=CC=C2)F)=N1)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.