Fig. 1 · Structure
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SJ6986
GSPT1/2 Degrader
SJ6986 is a potent and selective molecular glue degrader targeting GSPT1 and GSPT2, exhibiting a DC50 of 2.1 nM with a maximum degradation (Dmax) of 99% for GSPT1. This compound facilitates the targeted degradation of these proteins, making it a valuable tool for research into proteostasis and cellular stress responses. SJ6986 can be utilized in studies focusing on cancer biology and therapeutic strategies aimed at modulating protein levels within cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2765625-93-0 |
| Applications | GSPT1/2 Degrader |
| Formula | C20H14F3N3O7S |
| Molecular Weight | 497.40 |
| SMILES | O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.