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SjDX5-53

Catalog No.: A35434
TLR2 Inducer
SjDX5-53 is a selective TLR2 inducer derived from a 3 kDa peptide sourced from Schistosoma japonicum eggs. This compound effectively inhibits inflammatory Th1 and Th17 responses by inducing tolerogenic dendritic cells (tolDCs) while promoting the generation of regulatory T cells (Tregs) and enhancing their suppressive capacity. SjDX5-53 is primarily employed in research focused on autoimmune and inflammatory diseases, including colitis and psoriasis.
SjDX5-53 2767993-73-5 TLR2 Inducer
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSjDX5-53 is a selective TLR2 inducer derived from a 3 kDa peptide sourced from Schistosoma japonicum eggs. This compound effectively inhibits inflammatory Th1 and Th17 responses by inducing tolerogenic dendritic cells (tolDCs) while promoting the generation of regulatory T cells (Tregs) and enhancing their suppressive capacity. SjDX5-53 is primarily employed in research focused on autoimmune and inflammatory diseases, including colitis and psoriasis.
Product Information
Catalog NumA35434
FormulaC128H208N46O46S3
Molecular Weight3223.50
CAS Number2767993-73-5
SequenceGly-Gln-Met-Gln-Gln-Gln-Gln-Arg-Pro-Gln-Gln-Met-Gln-Pro-Ser-Gln-Gln-Tyr-Ala-Thr-Asn-Gln-Met-Thr-Asn-Ser-Arg
Sequence shorteningGQMQQQQRPQQMQPSQQYATNQMTNSR
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CCC(N)=O)=O)CCSC)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CO)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCSC)=O)CCC(N)=O)=O)CC(N)=O)=O)[C@@H](C)O)=O)C)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CO)=O)CCC2)CCC(N)=O)=O)CCSC)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC1
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Immunology & Inflammation > Toll-like Receptors