SJFα

Catalog No.: A18602

13-atom linker PROTAC

SJFα

SJFα Chemical Structure

CAS NO. 2254609-27-1

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.93 mL 44.63 mL 89.26 mL
0.5 mM 1.79 mL 8.93 mL 17.85 mL
1 mM 0.89 mL 4.46 mL 8.93 mL
5 mM 0.18 mL 0.89 mL 1.79 mL

*The above data is based on the productmolecular weight 1120.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18602
M. Wt 1120.27
Formula C59H67F2N7O11S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2254609-27-1
Synonyms SJF-α, SJF α
SMILES FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[[email protected]@H](C(C)(C)C)C(N5[[email protected]](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1

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