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Biological Activity
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.93 mL | 44.63 mL | 89.26 mL |
| 0.5 mM | 1.79 mL | 8.93 mL | 17.85 mL |
| 1 mM | 0.89 mL | 4.46 mL | 8.93 mL |
| 5 mM | 0.18 mL | 0.89 mL | 1.79 mL |
*The above data is based on the productmolecular weight 1120.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18602 |
|---|---|
| CAS No. | 2254609-27-1 |
| Formula | C59H67F2N7O11S |
| M. Wt | 1120.27 |
| Purity | >98% |
| Synonyms | SJF-α, SJF α |
| SMILES | FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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