SJFα

Catalog No.: A18602

13-atom linker PROTAC

SJFα

SJFα Chemical Structure

CAS NO. 2254609-27-1

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $350.00

Special Price $280.00

10 mg

Regular Price: $650.00

Special Price $520.00

50 mg

Regular Price: $2,000.00

Special Price $1,600.00

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Biological Activity

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.93 mL 44.63 mL 89.26 mL
0.5 mM 1.79 mL 8.93 mL 17.85 mL
1 mM 0.89 mL 4.46 mL 8.93 mL
5 mM 0.18 mL 0.89 mL 1.79 mL

*The above data is based on the productmolecular weight 1120.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18602
CAS No. 2254609-27-1
Formula C59H67F2N7O11S
M. Wt 1120.27
Purity >98%
Synonyms SJF-α, SJF α
SMILES FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[[email protected]@H](C(C)(C)C)C(N5[[email protected]](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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