SK-575

Name: SK-575
Brand: Adooq Bioscience
SKU: A23938
Rating: 5 (288 reviews)

Catalog No.: A23938

PARP1 Degrader

SK-575 is a highly potent and selective PROTAC degrader of PARP1, with an IC₅₀ of 2.30 nM. It effectively inhibits the proliferation of cancer cells harboring BRCA1/2 mutations, making it a valuable agent for targeted cancer research.

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Biological Activity

Description	SK-575 is a highly potent and selective PROTAC degrader of PARP1, with an IC₅₀ of 2.30 nM. It effectively inhibits the proliferation of cancer cells harboring BRCA1/2 mutations, making it a valuable agent for targeted cancer research.

Product Information

Catalog Num	A23938
Formula	C47H53FN8O8
Molecular Weight	876.97
CAS Number	2523016-96-6
SMILES	O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCCCCCCCCC(N4CCN(C(C5=CC(CC6=NNC(C7=C6C=CC=C7)=O)=CC=C5F)=O)CC4)=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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