Fig. 1 · Structure
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SK2187
AURKA PROTAC Degrader
SK2187 is a selective degrader of Aurora kinase A (AURKA) utilizing the PROTAC technology, exhibiting a DC50 of approximately 10 nM. This compound demonstrates significant growth inhibition of NGP neuroblastoma cells, with an IC50 value of 101.5 nM. SK2187 is particularly relevant for research on MYCN-amplified neuroblastoma, enabling exploration of targeted degradation pathways in cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3038446-91-9 |
| Applications | AURKA PROTAC Degrader |
| Formula | C45H49ClFN7O11S |
| Molecular Weight | 950.43 |
| Synonyms | JB301 |
| SMILES | O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=O)=C3C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.