SKF 104976 is a selective inhibitor of HMG-CoA reductase (HMGCR), demonstrating significant inhibitory activity in biochemical assays. It effectively reduces cholesterol synthesis in Hep G2 cells by inhibiting the incorporation of [14C]acetate at concentrations as low as 2 nM, leading to the accumulation of lanosterol and a substantial decrease in HMGR activity by 40-70%. Importantly, SKF 104976 does not influence low-density lipoprotein uptake or degradation, indicating a distinct regulatory mechanism for HMGR and low-density lipoprotein receptors. This compound serves as a valuable tool for studying cholesterol metabolism and the regulation of sterol synthesis pathways in cellular models.
SKF 104976 is a selective inhibitor of HMG-CoA reductase (HMGCR), demonstrating significant inhibitory activity in biochemical assays. It effectively reduces cholesterol synthesis in Hep G2 cells by inhibiting the incorporation of [14C]acetate at concentrations as low as 2 nM, leading to the accumulation of lanosterol and a substantial decrease in HMGR activity by 40-70%. Importantly, SKF 104976 does not influence low-density lipoprotein uptake or degradation, indicating a distinct regulatory mechanism for HMGR and low-density lipoprotein receptors. This compound serves as a valuable tool for studying cholesterol metabolism and the regulation of sterol synthesis pathways in cellular models.
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