SKF 10810

Catalog No.: A66965
GABAA Receptor Antagonist
SKF 10810 is a GABAA receptor antagonist with an EC50 of 4.3 μM, demonstrating a notable capacity to inhibit GABAergic signaling. By disrupting GABA-mediated inhibition in reward pathways of the brain, SKF 10810 may have potential antidepressant effects. This compound serves as a valuable tool for research into neurological disorders and the mechanisms underlying mood regulation.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSKF 10810 is a GABAA receptor antagonist with an EC50 of 4.3 μM, demonstrating a notable capacity to inhibit GABAergic signaling. By disrupting GABA-mediated inhibition in reward pathways of the brain, SKF 10810 may have potential antidepressant effects. This compound serves as a valuable tool for research into neurological disorders and the mechanisms underlying mood regulation.
Product Information
Catalog NumA66965
FormulaC19H20F3NO
Molecular Weight335.36
CAS Number22196-65-2
SMILESFC(C1=CC(C(CCCN(C)C)C2=C(C=CC=C2)O3)=C3C=C1)(F)F
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